An NLRP7-Containing Inflammasome Mediates Recognition of Microbial Lipopeptides in Human Macrophages
نویسندگان
چکیده
منابع مشابه
An NLRP7-containing inflammasome mediates recognition of microbial lipopeptides in human macrophages.
Cytosolic pathogen- and damage-associated molecular patterns are sensed by pattern recognition receptors, including members of the nucleotide-binding domain and leucine-rich repeat-containing gene family (NLR), which cause inflammasome assembly and caspase-1 activation to promote maturation and release of the inflammatory cytokines interleukin-1β (IL-1β) and IL-18 and induction of pyroptosis. H...
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ژورنال
عنوان ژورنال: Immunity
سال: 2012
ISSN: 1074-7613
DOI: 10.1016/j.immuni.2012.02.001